Pharma Chemistry

Our Chemistry Department is having One Professor, 1 Associate Professor and 4 assistant Professors for efficient teaching. The department is highly sophisticated with the Following equipment for conducting projects in drug design and synthetic chemistry.

  1. HPLC
  2. TLC
  3. FTIR
  4. UV Spectrophotometer
  5. Cooling Ultracentrifuge
  6. Rota vacuum Evaporator

Apart from this the college is having Schrodinger software for conducting projects in drug design.

The list of publications from the department of Chemistry are given below.

Publications

S.No Name of the Title of the publication Name of the Journal with month & year
1 Calculation of Relative Bindingattinities of Fructose 1,6

Bisphosphatose Mutants with

Adnosine monophosphate using free

Energy perturbation method.

 

J.Computational Chemistry 28:932-937, 2007.
2 Synthesis and Pharmaceuticalevaluation of new 2,6-disubstituted

2H-Pyridazin-3-ones Indian.

J. Pharmaceutical Research vol.6, No.3, July 2007: 166-169.
3 Virtual Screening of Carhepsin Kinhibitors Using Docking and

pharmacophore models.

Chem.Biol. Drug Des.2008; 72: 79-90.

 

 

4 SYNTHESIS OF SOME NEW

IMIDAZO[1,2-b]PYRIDAZINES

International Journal of Pharmaceutical Sciences and Nanotechnology (Volume 2.Issue1.April-June 2009).
5 Advances in binding Free Energies calculations: QM/MM-Based Free Energy perturbation method. Journal of Current Pharmaceutical Design (Vol 19,Number 26 August 2013 4674-86)
6 Synthesis and Docking studies of novel 2-substituted -6-Aryl pyridazin-3(2H) –ones as 5HT2AA antagonists. International Journal of computational and medicinal chemistry 2013, 01(1), 8-18.

TITLES OF THE THESIS SUBMITTED BY THE STUDENTS OF M. PHARMACY (PHARMACEUTICAL CHEMISTRY) FOR PARTIAL FULFILLMENT FOR AWARD OF DEGREE(NOVEMBER 2012)

S.No. Title of thesis
1 Synthesis & Docking studies of novel series of Pyridazine(6,1-c)(1,2,4) triazine derivatives as PDE4 inhibitors
2 Development of Industrial process for N-methyl pyridine-2-aldoxamine salts of Pharmaceutical importance.
3 A novel synthesis , Characterization and Docking studies of 2-Thio-Substituted Benzo(d)thiazole derivatives
4 Synthesis characterization and docking studies of 2-substitutd 6-aryl pyridizin -3(2H)-ones as Dopaminengic agents
5 Synthesis characterization and docking studies of some novel series of 7-(o-Triazolopyridazin-3yl)-4-methyl coumarins as cox-2 inhibitors
6 Synthesis,characterization, & docking studies of novel series of 2-[5(1H)tetrazolo]-yl-6-aryl-4,5-dihydro/dehydro-pyridazin-3(2H)-one
7 Synthesis and docking studies of 3,7-disubstituted Pyridazin[6,1-C][1,2,4)-Triazines as novel PDE-4 inhibitors
8 Synthesis and molecular modeling of novel 2–substituted -6-Aryl pyridazin-3(2H)ones as 5HT2A Antagonists
9 Synthesis, characterization and biological evaluation of Mannich bases of 7(hydroxyl)-4-methyl coumarin derivatives
10 Synthesis, Characterization and biological evaluation of novel 1,2,3 Tri-substituted Indoles
11 Synthesis, characterization and biological evaluation of a Schiff’s bases of 2-(2-oxo-2-aryl)ethyl Pyridazin-3-thiones.
12 Synthesis, Docking studies and in vitro evaluation of Novel 4-(benzo[d] thiazol-2-yl)-N-phenylalanine derivatives
13 Synthesis, characterization and Docking studies of Novel 6-Aryl – 2-(Piperidin-1-yl/Pyrrolidin-1-yl) Benzothiazole derivatives.
14 Molecular docking & Virtual screening for Novel protein tyrosine Phosphatane 1B(PTPIB) inhebitors
15 Homology Modeling & validation of Human FGFR 4 tyrosine kinase domine using structure based studies
16 In-Silico of Inhibitors for the Human SIAH2, implications for Hypoxia- induced cancers.

TITLES OF THE DISSERTATION SUBMITTED BY THE STUDENTS OF (M. PHARMACY) (PHARMACEUTICAL CHEMISTRY) FOR PARTIAL FULFILLMENT FOR AWARD OF DEGREE (NOVEMBER 2013)

S.No. Title of thesis
1 Synthesis, Charecterization, Docking studies and Biological evalution of 2,4,5,6 tetra substituted Pyridazin-3(2H)-ones
2 Synthesis, Characterization, Docking studies, and Biological evalution of Novel series of Sulfamoyl Phenyl Pyridazinones
3 Optimization, Charaterization & impurity profile of Telmisartian by improved synthetic rout and evaluation of Antihypertensive activity of impurity (Chloro analaog)
4 Synthesis, Characterization and Docking studies of Novel series of Pyridazinone substituted Benzene Sulfonyl Ureas
5 Synthesis, Characterization, Docking and Biological Evalution of Novel Pyrimido(4,5-C) Pyridazines
6 Synthesis, Characterization, and In-Sillico evalution of Phthalazine derivatives as Antihypertensive agents
7 Synthesis, Characterization, Docking studies, and Biological evalution of Novel series of 4 Pyrazolyl Substituted Pyridazinones
8 Synthesis, Characterization, Docking studies, and Biological evalution of Novel series of Mannich bases of pyridazin 3(2H) thione