RBVRR WOMEN'S COLLEGE OF PHARMACY
3-4-343, Barkathpura, Hyderabad - 500027, Ph: 040-27563065
Pharmaceutical chemistry, an amalgamation of basic chemistry and life sciences, is a multidisciplinary field that deals with the principles and applications natural, synthetic, computational and analytical chemistry in the discovery of chemical therapeutics for the prevention and cure of life threatening diseases. This is one of the major areas of drug discovery that caters the ever-increasing demand of new drug molecules for the effective medical practice against various diseases and disorders.
The pharmaceutical chemistry specialization of the department provides instructional and research training to the students in the areas of drug synthesis, characterization, drug testing etc.
This program was introduced in 2010. The course content is methodically structured and designed to prepare the students for a career in academia as well as the pharmaceutical industry. In addition to this, the program empowers students to continue to pursue higher studies and research activities.
The syllabus of the postgraduate program provides theoretical knowledge in a variety of topics related to drug design, advanced topics in medicinal chemistry, organic chemistry, process chemistry and analytical techniques in the first year of their academic career. The practical exercises that have been framed help the students to get practical skills in diverse areas like analytical techniques, drug synthesis, natural product isolation, physicochemical properties, separation techniques, etc. Seminars are part of the training program and it provides the opportunity to develop good communication and presentation skills. In the second year of their academic program, the students are allowed to carry out dissertations.
Department is enriched with various equipment’s required for UG Course and research. The department has conducive ambiance for study and research. The faculty of this department is encouraged and motivated to participate in National and International conferences /seminars and workshops. Besides faculty are actively involved in publishing research papers in National and International reputed journal of high impact value. The department provides adequate facilities to carry out research work.
The department is also very keen about the performance and moreover all the technical staffs are frequently imparted in-house training to enhance their performance and confidence.
The department gives emphasis on modification and simplification of various procedures to incorporate the practices of green chemistry in order to minimize the use of chemicals and avoid the hazardous effects. By and large, the department is making concerted efforts in pursuit of excellence and quality sustenance
Scope of the Program
Pharmaceutical Chemistry is a stimulating discipline which links many scientific disciplines and allows for collaboration with researchers from other disciplines like biologists, toxicologists, pharmacologists, theoretical chemists, microbiologists, and bio-pharmacists in developing new drugs. One can place herself in a competitive position by having a strong background in organic chemistry and medicinal chemistry.
Infrastructure and List of Instruments & Equipments
The Department of Pharmaceutical Chemistry has state-of the-art facilities to cater the needs of the Pharmacy profession in designing novel new drug entities. The laboratories are designed and equipped with several advanced facilities including central ventilation system and very sophisticated fume hoods attached with vacuum and water supply. Emergency kits and fire extinguishers are provided in each laboratory with a special focus on the safety of the workforce. The laboratories are spacious and ventilated having adequate space to carry out experimental work smoothly.
Skill Development in Pharmaceutical Chemistry Branch
A good imagination and persistence are the two important qualities a pharmaceutical chemist must possess. Since pharmaceutical chemists are team players in the drug discovery process, they must possess good written and verbal communication skills which are invaluable assets when interacting with scientists from other disciplines. The fact that their work helps to improve human health and reduce suffering is a strong motivating factor for chemists.
Core Competencies
Job Prospects in Pharmaceutical Chemistry
2010 – 2012
| R.No. | Name of the Student | Title of the Books |
| 1-001 | S.P.Anupama | Synthesis and Docking studies of novel series of Pyridazine (.1-c) (1,2,4) Triazines |
| 2-002 | Lateef Unnisa | Development of Industrial Proces for N-Methyl Pyridine -2- Aldoxime Salts of Pharmaceutical Importance |
| 3- 003 | P.Megha | A Novel Synthesis, Characterization And Docking Studies of 2-Thio-Substituted Benzo(d) Thiazole Derivatives |
| 4-004 | K.Rama | A Project Report on “Synthesis, Characterisation and Docking studies of some novel series of 7-(O-Triazolo pyridazin -3yl)-4- methyl coumarins”. |
| 5-005 | N.Mounika | Synthesis, Characterization and Docking Studies of Novel Series of 2-Substitued – 6- arylpyridazin-3(2H)- Ones as Dopaminergic agents. |
| 6-006 | A.Sravya | Synthesis and Docking Studies of Novel 2- Substituted -6- Arylpyridazine -3(2H)-Ones as 5HT2A Antagonists. |
| 7-007 | M.Sukanya | Synthesis, Characterisation and Anti Bacterial Activity of Mannich Bases of Coumarins. |
| 8-008 | N.S.P. Sirisha | Synthesis, Docking Studies and invitro CytotoxicEvaluation of Novel 4—(benzo(d) thiazol-2-yl)-N-Phenylaniline derivatives. |
| 9-009 | P.Spoorthi | Synthesis and Docking Studies of 3,7- Disubstituted-Pyridazin(8,1-c) (1,2,4) Triazines As Novel PDE-4 Inhibitors. |
| 10-010 | T.Vinayalaxmi | Synthesis, Characterization and Docking Studies of Novel 6-Aryl 2- (Piperidin-1-yl/pyrrolidin-1-yl) Bensothiazole Derivatives. |
| 11-011 | P.Saritha | Synthesis, Charcterization and Docking Studies of Novel Series of 2-(5(1H)- Tetrazolo)-YL-6-ARYL-4,5-Dihydro/Dehydro-Pyridazin-3(2H)-Ones. |
| 12-012 | P.V.Nageswari
| Synthesis, Characterization and Biological Evaluation of a Series of Schiff’s Bases of 2-(2-OXO-ARYL) Ehyl Pyridazin=3-Thiones. |
| 13-013 | K.Suneetha | Synthesis, Characterization and Biological Ebaluation of Novel 1,2,3-TRI-Substituted Indoles. |
| 14-014 | Poonam Chakravarthy | Homology Moderling and Validation of Human FGFR4-Tyrosine Kinase domain using Structure based Studies. |
| 15-015 | K.Rajitha | Molecular Docking and Virtual Screening for Novel inhibitors of Protein tyrosine phosphates 1B (PTP1B). |
| 16-016 | K.Sailaja | In-Silico Screening of Inhibitors for the Human Siah 2, Implications for Hypoxia- Induced Cancers. |
2011 – 2013
| R.No. | Name of the Student | Title of the Books |
| 1-001 | K.Geetha Reddy | Synthesis, Characterization, Docking Studies and Biological Evaluation of Some Novel 2,4,5,6 Tetra Substituted Pyridazin =3(2H) Ones. |
| 2-002 | K.P.Sunitha | Optimization, Characterization of Imputly Profile of Telmisartan By Improved Synthetic Activity of Impurity (Chloro Analog). |
| 3-003 | V. Tejaswini | Synthesis, Characterization, Docking Studies And Biological Ebaluation of Some Novel Mannich Bases of Pyridazin-3(2H)-Thione Derivatives. |
| 4-004 | N.Swetha | Synthesis, Characterization, Docking Studies And Biological Evaluation of Some Novel Pyrimido (4,5-c) Pyridazines. |
| 5-005 | D. Sai Sudha | Synthesis, Characterization and Docking Studies and Novel Seies of Pyridazinone Substituted Benzene Sulfonylureas. |
| 6-006 | S.Srujana | Synthesis, Characterization, Docking Studies and Biological Evaluation of Some Novel Sulfamoyl Phenyl Peridazinone. |
| 7-007 | R.Sumala | Synthesis, Charcterization and In-Silico Evaluation of Novel Phthalazine Derivatives as Antihypertensive Agents. |
| 8-008 | P.Spandana | Synthesis, Characterization, Docking Studies And Biological Ebaluation of Some Novel 4-Pyrazolyl Substituted Pyridazin -3(2H)- Ones. |
2012 – 2014
| R.No. | Name of the Student | Title of the Books |
| 1-001 | Priyanka Reddy. Vangala | Insilico Screening of Novel HSP90 Inhibitors Based on Imidiaso Pyrimidines / Bensimidazoles Substituted Derivatives by 3DQSAR And Docking. |
| 2-002 | Preethi. B | Homology Modeling of Stat3 Protein And Virtual Screening of Stat3 Inhibitors Based on Tetrazole / Quinazolin/ Thiophene Substituted Amides by Docking And 3DQSAR Studies. |
| 3- 004 | Amreen Begum | 3DQSAR, Docking And Adme Studies of Novel 1,2 Bensisothiazol 3(2H)-One, Oxidiazole & Other Hybrid Derivatives As Potent Inhibitors of Dengue Virus NS2B/NS3. |
| 4-005 | Mounika , Morampudi | Virtual Screening of JAK2 Inhibitors Based on Pyrrolotriazines/ Triazolopyridines by 3DQSAR And Docking. |
| 5-006 | Sri Vidya , Chitukula | Homology Modeling of Transient Receptor Potential Vanilliod, (TRPV1) And Insilico Screening of Novel TRPV1 Inhibitors Based on Diarylpentadienamide Derivatives By 3D-QSAR And Docking Studies. |
| 6-007 | Haritha, Somavar | In Silico Screening of H-Imidazo(4,5-B) PYRIDIN-2(3H)- Onederivatives As Novel Inhibitors of B Rafkinase By 3DQSAR And Docking Studies. |
| 7-009 | Vamshi Priya, N | Virtual Screening of Novel Rho Kinase Inhibitors Based on Pyrazole Substituted Benzamides / Quinazolines And Other Amides By 3D QSAR And Docking Studies. |
| 8-010 | Madeni Ayesha | In Silico Screening of Novel Inhibitors of 5-LOX Based On Naphthyl Prinixic Acid/Indole Derivatives By 3D QSAR And Docking Studies. |
| 9-011 | Mounika, Are | Molecular Modeling of Indolinone Derivatives As Transforming Growth Factor Beta Receptori (TGFBR1) Inhibitors By 3D QSAR And Docking Studies Based On fused Nitrogen Containing Heterocycles. |
2013 – 2015
| R.No. | Name of the Student | Title of the Books |
1-001 2013-15 | M.Kavitha Roll.No.170613884001 | Isolation, Characterization of phytochemical constituents and pharmacological investigation of Cissus vitiginea leaves. |
2012- 2016
<tdclass=”faltable” width=”66″>R.No.
| Name of the Student | Title of the Books | |
| 1-012 | S. Namitha | Molecular docking Pharmacophore Mapping and admet studies of Benzimidazole derivatives as inhi- bitors of Human Cyclin Dependent Kinase 2 enzyme. |
2016-2018
| R.No. | Name of the Student | Project Titles |
| 1-001 | Sadiya Fatima Roll. No:1706-16-884-001 | synthesis, characterization and biological evaluation of 2-hydroxy-2-methyl-6-arys-2-3-dihyro-7h-[1,3] thiazolo [3,2-b] [pyridazine. |
| 2-004 | Haleema Zainab Begum Roll. No:1706-16-884-004 | Synthesis, Characterization, Biological activity of Some Novel Mannich Bases of Pyridazine -3(2H)- Ones Derivatives. |
2017-2019
| R.No. | Name of the Student | Project Titles |
| 1-001 | A. Monalika Roll. No:1706-17-884-001 | Design Molecular Docking Synthesis And Biological Evaluation of Novel 2,5-Substituted Imidazole Derivatives As Anti-Inflammatory Agents. |
| 2-002 | Akula Akhila Sai Roll. No:1706-17-884-002 | Design Molecular Docking Synthesis Biological Evaluation of 4,5-Substituted 1,2,3-Triazoles As Antibacterial Agents. |
| 3-003 | Ayesha Begum Roll.No:1706-17-884-003 | Isolation And Characterization of Phytochemicals From Leaves of Cissus Pallida. |
| 4-004 | B. Naga Jyothi Roll.No:1706-17-884-004 | Synthesis Molecular Docking And Anti-Diabetic Evaluation of Some New Sulphonamido Substituted Imidazolone Derivatives. |
5-005
| P. Shravani Roll.No:1706-17-884-005 | Synthesis Molecular Docking, and Anti Bacterial Activity of Some New 3-Sulphonamido Substituted Quinazolinone Derivatives. |
2016-2019
| R.No. | Name of the Student | Project Titles |
| 1-002 | Jadi Amani Rani Roll. No:1706-16-884-002 | Synthesis, Characterization And Biological Evaluation Series of Schiffs Bases of 2-(2-OXO-2-Methyl)-Propyl 6-Aryl- 4,5-Dihydro Pyridazine-3-Thiones. |
2018-2020
| S.No. | Name of the Student | Project Titles |
| 4002 | Syeda Advia Sanobar | Structure Based Virtual Screening, Design, Synthesis, And Biological Evaluation Of 3-Sulfonamido Substituted Quinazolinones As Anti- Zika Viral Agents |
| 4004 | Zaberunnisa | Synthesis, Characterization, Molecular Docking And Biological Evaluation Of N-(Benzyloxy)-1h-Indole-2- Carboxamide Derivatives |
| 4005 | K. Sreelatha | Structure Based Virtual Screening, Design, Synthesis And Biological Evaluation Of Imidazoles As Antidiabetic Agents |
| 4006 | Nagma Begum | Synthesis, Characterization, Molecular Docking And Biological Evaluation Of 6-Methoxy-Benzothiazol-2-Yl-Amide Derivatives |
S.No.
|
Roll no. | Name of the Student |
Project Title |
| 1 | 31 | K. Mounika | Synthesis, characterisation of 7-Substituted-4-Methyl coumarin derivatives as anti-inflammatory agents. |
| 2 | 84 | S. Vagdevi | Ligand based virtual screening of coumarin derivatives as NHE (Na+/H+ exchange) inhibitors for the treatment of cancer |
| 3 | 80, 77 | Syeda rabab Fatima & k. sushma | Mechanochemical synthesis of novel-4-arylidine oxazolone derivatives |
| 4 | 83 | Usha Shalini | Ligand based virtual screening of pyrimidine derivatives in the treatment of NIPAH virus infections |
| 5 | 59 | Sai bhavani | Design and virtual screening of pyrimidine derivatives as potent anticancer agents. |
| 6 | 28 | G. Manasa | Design and virtual screening of novel inhibitors of NS2B-NS3 protease in the treatment of Dengue viral infections |
| 7 | 16 | V. Chandrika | Design and virtual screening of Quinoline derivatives as InhA (enoyl acyl carrier protein reductase) inhibitors for the treatment of tuberculosis
|
| 8 | 87 | Vindyasree | Design and virtual screening of beta carboline derivatives as potent anticancer agents |
2016-2020
B.Pharmacy (CBCS) Mini Project Titles
From: 22nd April to 27th April 2024
Venue: RBVRR Women's College of Pharmacy
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